Miguel Prudêncio

Researcher. Biological Sciences. Malaria



Author databases


M. Prudêncio (2000) “Molecular Enzymology of the Copper-Containing Enzymes Involved in Denitrification”, PhD Thesis, University of East Anglia, UK

Book Chapters

 L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Ranga-Prasad, J. Meissner, A. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M.P. Rodrigues, M. Mota, V. Sundaramurthy (2021) “Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite’s Liver Stage Development”, In Lange, S. and Ramirez, M.I. (Eds) Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses, Frontiers Media SA, Lausanne. doi: 10.3389/978-2-88966-580-8

A.M. Mendes, A. Scholzen, A.K. Mueller, S.M. Khan, R.W. Sauerwein, M. Prudêncio (2017) “Whole Organism Pre-Erythrocytic Vaccines”, In: Rodriguez, A. and Mota M.M. (Eds) Malaria: immune response to infection and vaccination, Springer International Publishing, Cham, Switzerland

M. Prudêncio, C.D. Rodrigues, M.M. Mota (2006) “The relevance of host genes in Malaria”, In: Parrington,J. and Coward, K. (Eds) Comparative Genomics and Proteomics in the Identification of New Drug Targets, Taylor & Francis, Oxford, UK, SEB Exp. Biol. Ser., 58, 47-91

Opinion Articles and Essays

5. M. Prudêncio (2021) “The role of science during pandemics”, In ‘Highlights 2020, Instituto de Medicina Molecular João Lobo Antunes’, Lisboa, Portugal

4. M.M. Mota, M. Prudêncio (2021) “O tempo em biologia / Time in biology”. In ‘O tempo na ciência e na música / Time in science and music’, Norprint Artes Gráficas, S.A., Santo Tirso, Portugal

3. M. Prudêncio (2021) “Portugal’s prominence in malaria research”, EMBO Reports, e51692 

2. M. Prudêncio (2020) “In fairness to mosquitoes”, Trends in Parasitology, 36, 876-877

1. M. Prudêncio, J.C. Costa (2020) “Research funding after COVID-19”, Nature Microbiol., 5, 986

Scientific Articles

154. A.T. Silva, I. Oliveira, D. Duarte, D. Moita, M. Prudêncio, F. Nogueira, R. Ferraz, E.F. Marques, P. Gomes (2024) ““Seasoning” antimalarial drugs’ action: chloroquine bile salts as novel triple-stage antiplasmodial hits”, RSC Med. Chem., DOI: 10.1039/D4MD00007B

153. K. Pavić, G. Poje, L. Pessanha de Carvalho, T. Tandarić, M. Marinović, D. Fontinha, J. Held, M. Prudêncio, I. Piantanida, R. Vianello, I. Krošl Knežević, I. Perković, Z. Rajić (2024), “Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds“, Bioorg. Med. Chem., 105, 117734

152. M. Fonte, C. Rôla, S. Santana, Y. Avalos-Padilla, X. Fernàndez-Busquets, M. Prudêncio, P. Gomes, C. Teixeira (2024), “Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial
”, Bioorg. Med. Chem.104, 117714

151. D. Moita, M. Prudêncio (2024), “A new malaria vaccination tool based on replication-competent Plasmodium falciparum parasites”, EMBO Mol. Med. 16, 667-669

150. M. Sulik, D. Fontinha, D. Steverding, S. Sobczak, M. Antoszczak, M. Prudêncio, A. Huczyński  (2024), “Unexpected rearrangement of ivermectin in the synthesis of new derivatives with trypanocidal and antiplasmodial activities”, Eur. J. Med. Chem., 263, 115951

149. A. Fraga, A.F. Mósca, D. Moita, J.P. Simas, H. Nunes-Cabaço, M. Prudêncio (2023), “SARS-CoV-2 decreases malaria severity in co-infected rodent models”, Front. Cell. Infect. Microbiol., 13, 1307553

148. D. Moita, H. Nunes-Cabaço, C. Rôla, B. Franke-Fayard, C.J. Janse, A.M. Mendes, M. Prudêncio  (2023), “Variable long-term protection by radiation-, chemo-, and genetically-attenuated Plasmodium berghei sporozoite vaccines, Vaccine, 41, 7618-7625

147. D. Moita, C. Rôla, H. Nunes-Cabaço, G. Nogueira, T.G. Maia, A.S. Othman, B. Franke-Fayard, C.J. Janse, A.M. Mendes*, M. Prudêncio*  (2023), “The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria, NPJ Vaccines, 182, 1-12. *Corresponding authors

146. M. Marinović, H. Rimac, L.P. de Carvalho, C. Rôla, S. Santana, K. Pavić, J. Held, M. Prudêncio, Z. Rajić (2023), “Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines”, Bioorg. Med. Chem., 94, 117468

145. M.J. Oliveira, S. Caetano, A. Dalot, F. Sabino,  T.R. Calmeiro, E. Fortunato, R. Martins, E. Pereira,  M. Prudêncio, H.J. Byrne, R. Franco,  H. Águas (2023) “A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites” Analyst, 148, 4053

144. G. da Silva, A.F.S. Luz, D. Duarte, D. Fontinha, V.L.M. Silva, F.A.A. Paz, A.M. Madureira, S. Simões, M. Prudêncio, F. Nogueira, A.M.S. Silva, R. Moreira (2023) “Facile access to structurally diverse antimalarial indoles using a one-pot A3 coupling and domino cyclization approach”, ChemMedChem, 18,  e2023002. Issue cover

143. S.S. Mendes, M. Sorg, C.M. Luís, D. Fontinha, D. Francisco, D. Moita, C.C. Romão, M.G. Pinho, C. Pimentel, M. Prudêncio, L.M. Saraiva (2023), “Conjugated Carbon Monoxide Releasing Molecules have broad-spectrum antimicrobial activity”, Fut. Med. Chem.15 (12), 1037-1048

142. M. Fonte, D. Fontinha, D. Moita, O. Caño-Prades, Y. Avalos-Padilla, X. Fernàndez-Busquets, M. Prudêncio, P. Gomes, C. Teixeira (2023), “New 4-(N-cinnamoylbutyl) aminoacridines as potential multi-stage antiplasmodial leads”, Eur. J. Med. Chem., 258, 115575

141. K.H. Breiterová, A. Ritomská, D. Fontinha, J. Kroustková, D. Suchánková, A. Hošt’álková, M. Šafratová, E. Kohelová, R. Perinová, R. Vrabec, D. Francisco, M. Prudêncio, Lucie Cahlíková (2023) “Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro”, Pharmaceutics, 15, 1007

140. J.F. Santos, R. Azevedo, M. Prudêncio, F. Marques, Y. Le Gal, D. Lorcy, C. Fernandes (2023) “Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity”, Pharmaceutics, 15, 1030

139. D. Moita, T.G. Maia, M. Duarte, C.M. Andrade, I.S. Albuquerque, A. Dwivedi, J.C. Silva, L. González-Céron, C.J. Janse, A.M. Mendes, M. Prudêncio (2022) “A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria”, NPJ Vaccines, 7, 163, 1-9

138. B. Franke-Fayard, C. Marin-Mogollon, F.J.A. Geurten, S. Chevalley-Maurel, J. Ramesar, H. Kroeze, E Baalbergen, E. Wessels, L. Baron, V. Soulard, T. Martinson, M. Aleshnick, A.T.G. Huijs, A.K. Subudhi, Y. Miyazaki, A.S. Othman, S. K. Kolli, O.A.C. Lamers, M. Roques, R.R. Stanway, S.C. Murphy, L. Foquet, D. Moita, A.M. Mendes, M. Prudêncio, K.J. Dechering, V.T. Heussler, A. Pain., B.K. Wilder, M. Roestenberg, C.J. Janse (2022) “Creation and preclinical 1 evaluation of genetically attenuated malaria parasites arresting growth late in the liver”, NPJ Vaccines, 7, 139, 1-17

137. A.J. Alves, N.G. Alves, I. Bártolo, D. Fontinha, S. Caetano, M. Prudêncio, N.Taveira, T.M. Pinho e Melo (2022) “Unveiling a family of spiro‐beta‐lactams with anti-HIV and anti-plasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates”, Front. Chem., 10, 1017250

136. H. Nunes-Cabaço, D. Moita, M. Prudêncio (2022) “Five decades of clinical assessment of whole-sporozoite malaria vaccines”, Front. Immunol., 13, 977472

135. I. Bouzón-Arnáiz, Y. Avalos-Padilla, A. Biosca, O. Caño-Prades, L. Román-Álamo, J. Valle, D. Andreu; D. Moita, M. Prudêncio, E.M. Arce, D. Muñoz-Torrero, X. Fernàndez-Busquets (2022) “The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures”, BMC Biology, 20, 197, 1-27

134. Y. Le Gal, A. Filatre-Furcate, D. Lorcy, O. Jeannin, T. Roisnel, V. Dorcet, D. Fontinha, D. Francisco, M. Prudêncio, M. Martins, C. Soeiro, S.A. Sousa, J.H. Leitão, T.S. Morais, I. Bártolo, N. Taveira, J.F. Guerreiro, F. Marques (2022) “Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes”, Int. J. Mol. Sci., 23, 7146

133. C.S. Pereira, H.C. Quadros, S.Y. Aboagye, D. Fontinha, S. D’Alessandro, M.E. Byrne, M. Gendrot, I. Fonta, J. Mosnier, D. Rodrigo, M. Moreira, N. Basilico, D.L. Williams, M. Prudêncio, B. Pradines, M. Navarro (2022) “Hybrid of amodiaquine and primaquine linked by gold(I) is a multistage antimalarial agent by targeting heme detoxification and thiol redox homeostasis”, Pharmaceutics, 14, 1251

132. A. Khandelwal, F. Arez, P.M. Alves, L. Badolo, C. Brito, C. Fischli, D. Fontinha, C. Oeuvray, M. Prudêncio, M. Rottmann, J. Wilkins, Ö. Yalkinoglu, W.M. Bagchus, T. Spangenberg (2022) “Translation of liver stage activity of M5717, a Plasmodium Elongation Factor 2 inhibitor – from bench to bedside”, Malaria J., 21, 151

131. H. Nunes-Cabaço, D. Moita, C. Rôla, A.M. Mendes, M. Prudêncio (2022) “Impact of dietary protein restriction on the immunogenicity and efficacy of whole-sporozoite malaria vaccination”, Front. Immunol., 13, 869757

130. E.A. Lopes, R. Mestre, D. Fontinha,J. Legac, J.V. Pei, M. Sanches-Vaz, M. Mori, A.M. Lehane, P.J. Rosenthal, M. Prudêncio, M.M.M. Santos (2022) “Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity”, Eur. J. Med. Chem, 236, 114324

129. D. Jublot, P. Cavaillès, S. Kamche, D. Francisco, D. Fontinha, M. Prudêncio, J.-F. Guichou, G. Labesse, D. Sereno, C. Loeuillet (2022)  “A Histone deacetylase (HDAC) inhibitor with pleiotropic in vitro anti-Toxoplasma and Plasmodial activities controls acute and chronic toxoplasma infection in mice”, Int. J. Mol. Sci., 23, 3254

128. D. Fontinha*, F. Arez*, I.R. Gal, G. Nogueira, D. Moita, T.H.H. Baeurle, C. Brito, T. Spangenberg**, P.M. Alves**, M. Prudêncio** (2022) “Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models”, ACS Inf. Dis., 8, 721-727*Equally contributing authors; **Corresponding authors.

127. A.F. Chora, M.M. Mota, M. Prudêncio (2022) “The reciprocal influence of the liver and blood stages of the malaria parasite’s life cycle”, Int. J. Parasitol., 52, 711-715

126. S. Portugal, A. Rodriguez, M. Prudêncio (2022) “Maria M. Mota: Bringing Plasmodium Liver Infection to the Centre Stage of Malaria Research”, Front. Cell. Infect. Microbiol., 12, 851484

125. L. Singh, D. Fontinha, D. Francisco, M. Prudêncio, K. Singh (2022) “Synthesis and Antiplasmodial Activity of Regioisomers and Epimers of Second-Generation Dual Acting Ivermectin Hybrids“, Sci. Rep., 12, 564

124. C. Upadhyay, N. Sharma, S. Kumar, P.P. Sharma, D. Fontinha, B.S. Chhikara, B. Mukherjee, D. Kumar, M. Prudêncio, A.P. Singh, Poonam (2022) “Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum”, New. J. Chem., 46, 250

123. A.T. Silva, I.S. Oliveira, J. Gomes, L. Aguiar, D. Fontinha, D. Duarte, F. Nogueira, M. Prudêncio, E.F. Marques, C. Teixeira, R. Ferraz, P. Gomes (2021) “Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase blood-stage antimalarial activity of primaquine“, ChemMedChem, e202100650

122. H.C. Quadros, A. Çapcı, L. Herrmann, S. D’Alessandro, D. Fontinha, R. Azevedo, W. Villarreal, N. Basilico, M. Prudêncio, S.B. Tsogoeva, D.R.M. Moreira (2021) “Studies of Potency and Efficacy of an Optimized Dihydroartemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle”, Pharmaceuticals, 14, 1129

121. T. Araki*, J. Lin*, M. Prudêncio*, D.A. Cunningham*, T. Annoura* (2021), “Editorial Malaria Targeting Toolkit: Host-Parasite Interactions”, Front. Cell. Infect. Microbiol., 11, 795494 *Corresponding authors 

120. A. Temporão*, M. Sanches-Vaz*, R. Luís, H. Nunes-Cabaço, T.K. Smith, M. Prudêncio**, L. Figueiredo** (2021) “Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection”, PLoS Negl. Trop. Dis.October 29. * Equally contributing authors; **Corresponding authors. Recommended by Faculty Opinions

119. M. Marinović, G. Poje, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L.P. Carvalho, T. Tandarić, R. Vianello, Z. Rajić (2021), “Further investigation of harmicines as novel antiplasmodial agents: Synthesis,structure-activity relationship and insight into the mechanism of action”, Eur. J. Med. Chem., 224, 113687

118. C.S.Pereira, H.C. Quadros, D.R.M. Moreira, W. Castro, Silva R.I.S.D.S., M.B.P. Soares, D. Fontinha, M. Prudêncio, V. Schmitz, H.F. Santos, M. Gendrot, I. Fonta, J. Mosnier, B. Pradines, M.Navarro (2021), “A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent”, ChemMedChem, 16, 662-678

117. D. Moita, H. Nunes-Cabaço, A.M. Mendes, M. Prudêncio (2021) “A guide to investigating immune responses elicited by whole-sporozoite pre-erythrocytic vaccines against malaria”, FEBS J.doi:10.1111/febs.16016

116. T.A. Tavella, N.S.M. Silva, N. Spillman, A.C.A.V.K., G.C. Cassiano, A.A. Vasconcelos, A.P. Camargo, D.C.B. Silva, D. Fontinha, L.C.S. Alvarez, L.T. Ferreira, K.C.P. Tomaz, B.J. Neves, L.D. Almeida, D.Y. Bargieri, M.V.G. Lacerda, P.V.L. Cravo, P. Sunnerhagen, M. Prudêncio, C.H. Andrade, S.C.P. Lopes, M.F. Carazzolle, L. Tilley, E. Bilsland, J.C. Borges, F.T.M. Costa (2021) “Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity”, ACS Infect. Dis., 7, 759-776

115. N.G. Alves, I. Bártolo, A.J.S. Alves, D. Fontinha, D. Francisco, S.M.M. Lopes, M.I.L. Soares, C. J.V. Simões, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2021) “Synthesis and structure-activity relationships of new chiral spiro-b-lactams highly active against HIV-1 and Plasmodium”, Eur. J. Med. Chem., 219, 113439

114. M. Prudêncio (2021) “Portugal’s prominence in malaria research”, EMBO Reports, e51692

113. I Bártolo, B.S. Santos, D. Fontinha, M. Machado, D. Francisco, B. Sepodes, J. Rocha, H. Mota-Filipe, R. Pinto, M.E. Figueira, H. Barroso, T. Nascimento, A.P.A. de Matos, A.J.S. Alves, N.G. Alves, C.J.V. Simões, M. Prudêncio, T.M.V.D. Pinho e Melo, N. Taveira (2021) “Spiro-β-lactam BSS-730A displays potent activity against HIV and Plasmodium”, ACS Infect. Dis., 7, 2, 421-434

112. M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M.J. Araújo, X. Fernàndez-Busquets, M. Prudêncio, P. Gomes, C. Teixeira (2021) “4,9-diaminoacridines and 4-aminoacridines as antiplasmodial hits”, ChemMedChem, 16, 799-792

111. Y. Miyazaki, C.Y. Marin, T. Imai, A.M. Mendes, R. vd Laak, A. Sturm, F.J. Geurten, S. Miyazaki, S.C. Chevalley-Maurel, J. Ramesar, S.K. Kolli, J. Kroeze, R. van Schuijlenburg, A.M. Salman, B.K. Wilder, A. Reyes-Sandoval, K. Dechering, M. Prudêncio, C.J. Janse, S.M. Khan, B. Franke-Fayard (2020) “Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing P. vivax circumsporozoite protein for malaria vaccine development”, Front.  Cell. Infect. Microbiol., 10, 591046

110. P. Meireles, D. Brás, D. Fontinha, A.F. Chora, K. Serre, A.M. Mendes*, M. Prudêncio* (2020) “Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation”, iScience, 23, 101781(*Corresponding authors). Recommended by Faculty Opinions

109. M. Marinović, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L. Pessanha de Carvalho, T. Tandarić, R. Vianello, B. Zorc, Z. Rajić (2020) “Novel Harmicines with Improved Potency against Plasmodium”, Molecules, 25, 4376

108. M. Prudêncio (2020) “In fairness to mosquitoes”, Trends Parasitol., 36, 876-877

107. S.A. Milheiro, J. Gonçalves, R.M.R.M. Lopes, M. Madureira, L. Lobo, A. Lopes, F. Nogueira, D. Fontinha, M. Prudêncio, M.F.M. Piedade, S.N. Pinto, P.R. Florindo, R. Moreira (2020) “Half- sandwich cyclopentadienylruthenium(II) complexes: a new antimalarial chemotype”, Inorg. Chem., 59, 12722-12732

106. D. Fontinha, I. Moules, M. Prudêncio (2020) “Repurposing drugs to fight hepatic malaria parasites”, Molecules, 25, 3409

105. M. Prudêncio, J.C. Costa (2020) “Research funding after COVID-19”, Nature Microbiol., 5, 986

104. D. Fontinha, S.A. Sousa, T.S. Morais, M. Prudêncio, J.H. Leitão, Y.L. Gal, D. Lorcy, R.A.L. Silva, M.F.G. Velho, D. Belo, M. Almeida, J.F. Guerreiro, T. Pinheiro, F. Marques (2020) “Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents”, Metallomics12, 974-987

103. I.J. Reuling*, A.M. Mendes*, G.M. de Jong GM*, A. Fabra-García*, H. Nunes-Cabaço*, G.J. van Gemert, W. Graumans, L.E. Coffeng, S.J. de Vlas, A.S.P. Yang, C.K. Lee, Y. Wu, A.J. Birkett, C.F. Ockenhouse, R. Koelewijn, J.J. van Hellemond, P.J.J. van Genderen**, R.W. Sauerwein**, M. Prudêncio** (2020) “Safety and efficacy of a genetically modified rodent malaria parasite against Plasmodium falciparum malaria: an open-label randomized phase 1/2a trial”, Science Transl. Med.,12, eaay2578. *Equally contributing authors; **Corresponding authors. Issue cover.

102. L. Singh, D. Fontinha, D. Francisco, A.M. Mendes, M. Prudêncio, K. Singh (2020) “Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites”, J. Med. Chem., 63, 1750-1762

101. R. Azevedo, A.M. Mendes, M. Prudêncio (2020) “The impact of antiretroviral therapy on malaria parasite transmission”, Front. Microbiol., 10, 3048

100. L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Prasad, J. Meissner, A.S. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M. Rodrigues, M.M. Mota, V. Sundaramurthy (2020) “Association of Plasmodium berghei with the apical domain of hepatocytes is necessary for the parasite’s liver stage development”, Front. Cell. Infect. Microbiol.,9, 451

99. I. Perković, S. Raić-Malić, D. Fontinha, M. Prudêncio, L.P. Carvalho, J. Held, T. Tandarić, R. Vianello, B. Zorc, Zrinka Rajić (2020) “Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits”, Eur. J. Med. Chem., 187, 11927

98. S.A. Sousa, J.H. Leitão, R.A.L. Silva, D. Belo, I.C. Santos, J.F. Guerreiro, M. Martins, D. Fontinha, M. Prudêncio, M. Almeida, D. Lorcy, F. Marques (2020) “On the Path to Gold: Monoanionic Au Bisdithiolate Complexes with 1 Antimicrobial and Antitumor Activities”, J. Inorg. Biochem., 202, 110904

97. A.J.S. Alves, N.G. Alves, C.C. Caratão, Esteves M., D. Fontinha, I. Bártolo, M.I.L. Soares, S.M.M. Lopes, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2020) “Spiro-Lactams as Novel Antimicrobial Agents”, Curr. Top. Med. Chem., 20, 140-152

96. M. Sanches-Vaz, A. Temporão, R. Luis, H. Nunes-Cabaço, A.M. Mendes, S. Goellner, T. Carvalho, L.M. Figueiredo*, M. Prudêncio* (2019) “Trypanosoma brucei infection protects mice against malaria”, PLoS Pathogens, 15, e1008145(* Corresponding authors)

95. R. Azevedo, A.M. Mendes, M.Prudêncio (2019) “Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins”, Parasites & Vectors, 12, 594

94. F. Arez, S. Rebelo, D. Fontinha, D. Simão, T.R. Martins, M. Machado, C. Fischli, C. Oeuvray, L. Badolo, M. J. T. Carrondo, M. Rottmann, T. Spangenberg, C. Brito, B. Greco*, M. Prudêncio*, P.M. Alves* (2019) “Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection”, ACS Infect. Dis., 5, 1831-1842 (* Corresponding authors)

93. K. Pavić, B. Rubinić, Z. Rajić, D. Fontinha, M. Prudêncio, L. Uzelac, M. Kralj, J. Held, B. Zorc (2019) “Primaquine homodimers as potential antiplasmodial and anticancer agents”, Bioorg. Med. Chem. Lett.,29, 126614

92. K. Wolanin, D. Fontinha, M. Sanches‐Vaz, B. Nyboer, Kirsten Heiss, A.-K. Mueller, M. Prudêncio (2019) “A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle”, Cell. Microbiol., e13088

91. M. Beus, D. Fontinha, J. Held, Z. Rajić, L. Uzelac, M. Kralj, M. Prudêncio, B. Zorc (2019) “Primaquine and chloroquine fumardiamides as promising antiplasmodial agents”, Molecules, 24, 2812

90. M. Beus, D. Fontinha, J. Held, Z. Rajić, M. Prudêncio, B. Zorc (2019) “Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides”, Acta Pharmaceutica, 69, 233-248

89. L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, Paula Gomes (2019) “Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites”, MedChemComm, 10, 221-226

88. G. Mayoka, M. Njoroge, J. Okombo, L. Gibhard, M. Sanches-Vaz, D. Fontinha, L.M. Birkholtz, J. Reader, M. van der Watt, T.L. Coetzer, S. Lauterbach, A. Churchyard, B. Bezuidenhout, T.J. Egan, C.L. Yeates, S. Wittlin, M. Prudêncio, K. Chibale (2019) “Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria”, J. Med. Chem., 62, 1022-1035

87. M. Kumar, J. Okombo, D. Mambwe, D. Taylor, N. Lawrence, J. Reader, M.V. Watt, D. Fontinha, M. Sanches-Vaz, B. Bezuidenhout, S. Lauterbach, D. Liebenberg, L.M. Birkholtz, T.L. Coetzer, M. Prudêncio, T.J. Egan, S. Wittlin, K. Chibale (2019) “Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action”, ACS Infect. Dis., 5, 303-315

86. A.M. Mendes, I.J. Reuling, C.M. Andrade, T.D. Otto, M. Machado, F. Teixeira, J. Pissarra, N. Gonçalves-Rosa, D. Bonaparte, J. Sinfrónio, M. Sanders, C.J. Janse, S.M. Khan, C.I. Newbold, M. Berriman, C. Lee, Y. Wu, C.F. Ockenhouse, R.W. Sauerwein, M. Prudêncio (2018) “Pre-Clinical Evaluation of a P. berghei-Based Whole-Sporozoite Malaria Vaccine Candidate”, NPJ Vaccines, 3, 54

85. M. Beus, Z.R. Džolić, D. Maysinger, Z. Mlinarić, M. Antunović, I. Marijanović, D. Fontinha, M. Prudêncio, J. Held, S. Olgen, B. Zorc (2018) “SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents”, ChemistryOpen,7, 624-638

84. A.M. Mendes, M. Machado, N. Gonçalves-Rosa, I.J. Reuling, L. Foquet, C. Marques, A.M. Salman, A.S.P. Yang, K.A. Moser, A. Dwivedi, C.C. Hermsen, B. Jiménez-Díaz, S. Viera, J.M. Santos, I. Albuquerque, S.N. Bhatia, J. Bial, I. Angulo-Barturen, J.C. Silva, G. Leroux-Roels, C.J. Janse, S.M. Khan, M.M. Mota, R.W. Sauerwein, M. Prudêncio (2018) “A Plasmodium berghei Sporozoite-Based Vaccination Platform Against Human Malaria”, NPJ Vaccines, 3, 33

83. R. Capela, J. Magalhães, D. Miranda, M. Machado, M. Sanches-Vaz, I.S. Albuquerque, M. Sharma, J. Gut, P.J. Rosenthal, R. Frade, M.J. Perry, R. Moreira, M. Prudêncio*, F. Lopes* (2018) “Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability”, Eur. J. Med. Chem., 149, 69-78. *- Corresponding authors

82. M. Šafratová, A. Hošťálková, D. Hulcová, K. Breiterová, V. Hrabcová, M. Machado, D. Fontinha, M. Prudêncio, J. Kuneš, J. Chlebek, D. Jun, M. Hrabinová, L. Nováková, R. Havelek, M. Seifrtová, L. Opletal, L. Cahlíková (2018) “Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity”, Arch. Pharm. Res., 41, 208-218

81. K. Pavic, I. Perkovic, S. Popisilova, M. Machado, D. Fontinha, M. Prudêncio, J. Jampilek, A. Coffey, L. Endersen, H. Rimac, B. Zorc (2018) “Primaquine hybrids as promising antimycobacterial and antimalarial agents”, Eur. J. Med. Chem., 143, 769-779

80. T.S. Macedo, W. Villarreal, C.C. Couto, D.R.M. Moreira, M. Navarro, M. Machado, M. Prudêncio, A.A. Batista, M.B.P. Soares (2017) “Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function”, Metallomics, 9, 1548-1561

79. M. Machado, M. Sanches-Vaz, J.P. Cruz, A.M. Mendes, M. Prudêncio (2017) “Inhibition of Plasmodium hepatic infection by antiretroviral compounds”, Front. Cell. Infect. Microbiol., 7, DOI: 10.3389/fcimb.2017.00329

78. P. Meireles, A.M. Mendes, R.I. Aroeira, B.C. Mounce, M. Vignuzzi, H.M. Staines, M. Prudêncio (2017) “Uptake and metabolism of arginine impact Plasmodium development in the liver”, Sci. Rep., 7, 4072

77. R. Azevedo, M. Markovic, M. Machado, B. Franke-Fayard, A.M. Mendes, M. Prudêncio (2017) “A bioluminescence method for in vitro screening of Plasmodium transmission-blocking compounds”, Antimicrob. Agents Chemother., 61, 202699-16

76. K. Singh, J. Okombo, C. Brunschwig, F. Ndubi, L. Barnard, C. Wilkinson, P.M. Njogu, M. Njoroge, L. Laing, M. Machado, M. Prudêncio, J. Reader, M. Botha, S. Nondaba, L.M. Birkholtz, S. Lauterbach, A. Churchyard, T.L. Coetzer, J.N. Burrows, C. Yeates, P. Denti, L. Wiesner, T.J. Egan, S. Wittlin, K. Chibale (2017) “Antimalarial pyrido[1,2-a]benzimidazoles: Lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics and in vivo oral efficacy in a mouse model”, J. Med. Chem., 60, 1432-1448

75. C.S. Cunha§, B. Nyboer§, K. Heiss, M. Sanches-Vaz, D. Fontinha, E. Wiedtke, D. Grimm, J.M. Przyborski, M.M. Mota, M. Prudêncio*, A.K. Mueller* (2017) “P. berghei EXP-1 Interacts with Host Apolipoprotein H during Plasmodium Liver Stage Development”, Proc. Natl. Acad. Sci. USA, 114, E1138-E1147§- Equally contributing authors; *- Corresponding authors

74. A.M. Mendes, I.S. Albuquerque, M. Machado, J. Pissarra, P. Meireles, M. Prudêncio (2017) “Inhibition of Plasmodium liver infection by ivermectin”, Antimicrob. Ag. Chemother., 61, e02005-16

73. M.A.S. Cavadas, M.P. Monopoli, C.S. Cunha, M. Prudêncio, E. Pereira, I. Lynch, K.A. Dawson, R. Franco (2016) “Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates”, Particle & Particle Systems Characterization, 33, 906-915

72. M.P. Carrasco*, M. Machado, L. Gonçalves, M. Sharma, J. Gut, A.K. Lukens, D.F. Wirth, V. André, M.T. Duarte, R.C. Guedes, D. dos Santos, P.J. Rosenthal, R. Mazitschek, M. Prudêncio*, R. Moreira (2016) “Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites”, ChemMedChem, 11, 2194-2204 (* Corresponding authors)

71. P. Meireles, J. Sales-Dias, C.M. Andrade, J. Mello-Vieira, L. Mancio-Silva, J.P. Simas, H.M. Staines, M. Prudêncio (2016) “GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection”, Cell. Microbiol., doi:10.1111/cmi.12646

70. R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. Prudêncio, S. Parapini, S. D’Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes (2016) “Primaquine-based ionic liquids as a novel class of antimalarial hits”, RSC Advances, 6, 56134-56138

69. T.S. Macedo, L.C. Vegas, M. Paixão, M. Navarro, B.C. Barreto, P.C.M..Oliveira, S.G. Macambira, M. Machado, M. Prudêncio, S. D’Alessandro, N. Basilico, D.R.M. Moreira, A.A. Batista, M.B.P. Soares (2016) “Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents”, Parasitology, 143, 1543-1556

68. C.J.A. Ribeiro, M. Espadinha, M. Machado, J. Gut, L.M. Gonçalves, P.J. Rosenthal, M. Prudêncio, R. Moreira, M.M.M. Santos (2016) “Novel squaramides with in vitro liver stage antiplasmodial activity”, Bioorg. Med. Chem., 24, 1786-1792

67. N. Terzić, J. Konstantinović, M. Tot, J. Burojević, O. Djurković-Djaković, J. Srbljanović, T. Štajner, T. Verbić, M. Zlatović, M. Machado, I.S. Albuquerque, M. Prudêncio*, R.J. Sciotti, S. Pecic, S. D’Alessandro, D. Taramelli, B.A. Šolaja* (2016) “Re-investigating old pharmacophores: Are 4-aminoquinolines and tetraoxanes potential two-stage antimalarials?”, J. Med. Chem., 59, 264-281 (* Corresponding authors)

66. I. Gomes, A. Reis, E. Pereira, E. Fortunato, M. Prudêncio, R. Franco (2015) “Nanoimunoensaios para diagnóstico de malária”, An. Inst. Hig. Med. Trop., 14, 21-30

65. N.A.L. Pereira, Â. Monteiro, M. Machado, J. Gut, E. Molins, M.J. Perry, J. Dourado, R. Moreira, P.J. Rosenthal, M. Prudêncio,* and M.M.M. Santos* (2015), “Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites”, ChemMedChem, 10, 2080-2089 (* Corresponding authors)

64. A. Gomes, M. Machado, L. Lobo, F. Nogueira, M. Prudêncio, C. Teixeira, P. Gomes (2015) “N-cinnamoylation of antimalarial classics: Effects of using acyl groups other than cinnamoyl toward dual-stage antimalarials”, ChemMedChem, 10, 1344-1349

63. H. Kaur, M. Machado, C. de Kock, P. Smith, K Chibale, M. Prudêncio, K. Singh (2015) “Primaquineepyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity”, Eur. J. Med. Chem., 101, 266-273

62. M.D. Lewis, J. Behrends, C.S. Cunha, A.M. Mendes, F. Lasitschka, K. Heiss, T.W.A. Kooij, M.Prudêncio, F.Frischknecht and A.-K. Mueller (2015), “Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression”, J. Immunol.194, 4860-4870

61. C.A.B. Rodrigues, R.F.M. Frade, I.S. Albuquerque, M.J. Perry, J. Gut, M. Machado, P.J. Rosenthal, M. Prudêncio, C.A.M. Afonso, R. Moreira (2015), “Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids”, ChemMedChem, 10, 883-890

60. P. Liehl, P. Meireles, I.S. Albuquerque, M. Pinkevych, F. Baptista, M.M. Mota, M.P. Davenport, M. Prudêncio (2015), “Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections”, Infect. Immun., 83, 1172-1180

59. C. Ramalhete, F.P. da Cruz, I.J. Sousa, S. Mulhovo, M.X. Fernandes, M. Prudêncio, M.-J.U. Ferreira (2014), “Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite”, Bioorg. Med. Chem., 22, 3887-3890

58. R. Oliveira, R.C. Guedes, P. Meireles, I.S. Albuquerque, L.M. Gonçalves, E. Pires, M.R. Bronze, J. Gut, P.J. Rosenthal, M. Prudêncio, R. Moreira, P.M. O’Neill, F. Lopes (2014), “Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials”, J. Med. Chem., 57, 4916-4923

57. D. Miranda, R. Capela, I.S. Albuquerque, P. Meireles, I. Paiva, F. Nogueira, R. Amewu, J. Gut, P.J. Rosenthal, R. Oliveira, M.M. Mota, R. Moreira, F. Marti, M. Prudêncio, P.M. O’Neill, F. Lopes (2014) “Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities”, ACS Med. Chem. Lett., 5, 108-112

56. A. Gomes, B. Pérez, I. Albuquerque, M. Machado, M. Prudêncio, F. Nogueira, C. Teixeira, P. Gomes (2014) “N-cinnamoylation of antimalarial classics: new quinacrine analogues with reduced toxicity and dual-stage activity”, ChemMedChem,9, 305-310

55. P. Liehl, V. Zuzarte-Luís, J. Chan, T. Zillinger, F. Baptista, D.l Carapau, M. Konert, K. Hanson, C. Carret, C. Lassnig, M. Müller, U. Kalinke, M. Saeed, A.F. Chora, D.T. Golenbock, B. Strobl, M. Prudêncio, L.P. Coelho, S.H. Kappe, G. Superti-Furga, A. Pichlmair, A.M. Vigário, C.M. Rice, K.A. Fitzgerald, W. Barchet, M.M. Mota (2014) “Host cell sensors for Plasmodium activate innate immunity against liver stage infection”, Nature Med.20, 47-53

54. A.S. Ressurreição, D. Gonçalves, A.R. Sitoe, I.S. Albuquerque, J. Gut, A. Góis, L.M. Gonçalves, M.R. Bronze, T. Hanscheid, G.A. Biagini, P.J. Rosenthal, M. Prudêncio, P. O’Neill, M.M. Mota, F. Lopes, R. Moreira (2013) “Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability”, J. Med. Chem., 56, 7679-7690

53. T. Rodrigues, A.S. Ressurreição, F.P. da Cruz, I.S. Albuquerque, J. Gut, M. Carrasco, D. Gonçalves, M.M. Mota, P.J. Rosenthal, R. Moreira, M. Prudêncio, F. Lopes (2013) “Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds”, Eur. J. Med. Chem.69, 872-880

52. K. Hanson, A.S. Ressurreição, K. Buchholz, M. Prudêncio, J. Herman, M. Rebelo, W. Beatty, D. Wyrth, T. Hanscheid, R. Moreira, M. Marti, M.M. Mota (2013) “Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins”, Proc. Natl. Acad. Sci. USA, 110, E2838-E2847 

51. T. Rodrigues, F.P. da Cruz, M. Lafuente-Monasterio, D. Gonçalves, A. Ressurreição, A.R. Sitoe, M.R. Bronze, J.Gut, G. Schneider, M.M. Mota, P.J. Rosenthal, M. Prudêncio, F.-J. Gamo, F. Lopes, R. Moreira (2013) “Quinolon-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria”, J. Med. Chem., 56, 4811-4815

50. E. Dempsey, M. Prudêncio, B.J. Fennell, C.S. Gomes-Santos, J.W. Barlow, A. Bell (2013) “Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites”, Mol. Biochem. Parasitol., 188, 116-127Highlighted as Feature Article on Malaria Nexus

49. J. Lin, P. Meireles, M. Prudêncio, S. Engelmann, T. Annoura, M. Sajid, S. Chevalley‐Maurel, J. Ramesar, C. Nahar, C.M.C. Avramut, A.J. Koster, K. Matuschewski, A.P. Waters, C.J. Janse, G.R. Mair, S.M. Khan (2013) “Loss‐of‐Function Analyses Defines Vital and Redundant Functions of the Plasmodium Rhomboid Protease Family”, Mol. Microbiol., 88, 318-338

48. B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, J.R.B. Gomes, M. Prudêncio, P. Gomes (2013) “N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads”, J. Med. Chem., 56, 556-567

47. M. Prudêncio*, Maria M. Mota* (2013) “Targeting host factors to circumvent anti-malarial drug resistance”, Curr. Pharm. Des., 19, 290-299 (Review) (* Corresponding authors)

46. B.C. Pérez, C. Teixeira, A.S. Gomes, I.S. Albuquerque, J. Gut, P.J. Rosenthal, M. Prudêncio, P. Gomes (2013) “In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites”, Bioorg. Med. Chem. Lett.,  23, 610-613 

45. B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, M. Prudêncio* , P. Gomes*(2012) “PRIMACINS, N-cinnamoyl-primaquine conjugates with improved liver-stage antimalarial activity”, Med. Chem. Commun., 3, 1170-1172 (* Corresponding authors) 

44. E.R. Derbyshire, M. Prudêncio, M.M. Mota, J. Clardy (2012) “Liver stage malaria parasites vulnerable to diverse chemical scaffolds”Proc. Natl. Acad Sci. USA109, 8511-8516

43. F.P. da Cruz, C. Martin, K. Buchholz K, M.J. Lafuente-Monasterio, T. Rodrigues, B. Sönnichsen, R. Moreira, F.J. Gamo, M. Marti, M.M. Mota, M. Hannus, M. Prudêncio* (2012) “Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multi-Stage Anti-Malarial Drug”, J. Inf. Dis., 205, 1278-1286Evaluated by Faculty of 1000 Biology and Medicine (*Corresponding author)

42. B.S.S. Guirgis, C.S. Cunha, I. Gomes, M. Cavadas, I. Silva, G. Doria, G.L. Blatch, P.V. Baptista, E. Pereira, H.M.E. Azzazy, M.M. Mota, M. Prudêncio, R. Franco (2012) ”Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection”, Anal. Bioanal. Chem., 402, 1019-1027

41. J. Matos, F.P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V.E. do Rosário, R. Moreira, P.J. Rosenthal , M. Prudêncio, P. Gomes (2012) “Novel potent metallocenes against liver stage malaria”, Antimicrob. Agents Chemother., 56, 1564-1570

40. T. Rodrigues, M. Prudêncio, R. Moreira, M.M. Mota, F. Lopes (2012) “Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal”, J. Med. Chem., 55, 995-1012

39. P. Eaton, V. Zuzarte-Luis, M.M. Mota, N.C. Santos, M. Prudêncio (2012) “Infection by Plasmodium changes shape and stiffness of hepatic cells”, Nanomedicine, 8, 17-19

38. C. Almeida, S. Kehraus, M. Prudêncio, G.M. König (2011) “Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp”, Beilstein J. Org. Chem., 7, 1636–1642

37. C. Ramalhete, F.P. da Cruz, D. Lopes, S. Mulhovo, V.E. Rosário, M. Prudêncio, M.J.U. Ferreira (2011) “Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections”, Bioorg. Med. Chem., 19, 7474-7481

36. M. Prudêncio*, M.M. Mota, A.M. Mendes (2011) “A toolbox to study liver stage malaria”, Trends Parasitol., 27, 565-574, Selected by MalariaNexus (*Corresponding author)

35. R. Capela, G.G. Cabal, P.J. Rosenthal, J. Gut, M.M. Mota, R. Moreira, F. Lopes, M. Prudêncio (2011) “Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy”,  Antimicrob. Agents Chemother., 55, 4698-4706 

34. C.S.S. Gomes-Santos§, J. Braks§, M. Prudêncio, C. Carret, A.R. Gomes, A. Pain, T. Feltwell, S. Khan, A. Waters, C. Janse, G.R. Mair, M.M. Mota (2011) “Transition of Plasmodium Sporozoites into Liver Stage-Like Forms Is Regulated by the RNA Binding Protein Pumilio”, PloS Pathogens, 7(5):e1002046 (§ Equally contributing authors)

33. J. Lavrado, G.G. Cabal, M. Prudêncio, M.M. Mota, J. Gut, P.J. Rosenthal, C. Díaz, R.C. Guedes, D.J. Dos Santos, E. Bichenkova, K.T. Douglas, R. Moreira, A. Paulo (2011) “Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies”, J. Med. Chem.,54, 734-750

32. K. Slavic, M.J. Delves, M. Prudêncio, A.M. Talman, U. Straschil, E.T. Derbyshire, Z. Xu, R.E. Sinden, M.M. Mota, C. Morin, R. Tewari, S. Krishna, H.M. Staines (2011) “Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite’s Life Cycle”, Antimicrob. Agents Chemother., 55, 2824-2830

31. P. Liehl, A.R. França, M. Prudêncio, E. Latz, A. Zaidman-Rémy, M.M. Mota (2010) “Phosphothioate Oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility”, Cell. Microbiol., 12, 506-515

30. I.H. Ploemen*, M. Prudêncio*, B.G. Douradinha, J. Ramesar, J. Fonager, G.J. van Gemert, A.J. Luty, C.C. Hermsen, R.W. Sauerwein, F.G. Baptista, M.M. Mota, A.P. Waters, I. Que, C.W. Lowik, S.M. Khan, C.J Janse, B.M. Franke-Fayard (2009) “Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging”, PLoS ONE, 4, e7881 (* Equally contributing authors)

29. N. Vale, M. Prudêncio, C.A. Marques, M.S. Collins, J. Gut, F. Nogueira, J. Matos, P.J. Rosenthal, M.T. Cushion, V.E. do Rosário, M.M. Mota, R. Moreira, P. Gomes (2009) “Imidazoquines as Antimalarial and Antipneumocystis Agents”, J. Med. Chem., 52, 7800-7807

28. M. Prudêncio*, E.T. Derbyshire*, C.A. Marques, S. Krishna, M.M. Mota, H.M. Staines (2009) “Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells”, Cell. Microbiol., 11, 1492-1501 (* Equally contributing authors)

27. S.S. Albuquerque, C. Carret, A.R. Grosso, A.S. Tarun, X. Peng, S.H.I. Kappe, M. Prudêncio, M.M. Mota (2009) “Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events”, BMC Genomics, 10, 270-282

26. M. Prudêncio, M.J. Lehmann (2009) “Illuminating the host – How RNAi screens shed light on host-pathogen interactions”, Biotechnol. J., 4, 826-837

25. I. Parvanova, S. Epiphanio, A. Fauq, T.E. Golde, M. Prudêncio, M.M. Mota (2009) “A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity”, PLoS ONE, 4, e5078

24. M. Prudêncio*, C.D. Rodrigues*, M. Hannus, C. Martin, E. Real, L .A. Gonçalves, C. Carret, R. Dorkin, I. Röhl, K. Jahn-Hoffmann, A.J.F. Luty, R. Sauerwein, C.J. Echeverri, M.M. Mota (2008) “Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection”, PloS Pathogens, 4, 1-15 (* Equally contributing authors)

23. M.G. Finiguerra, M. Prudêncio, M. Ubbink, M. Huber (2008) “Accurate Long-Range Distance Measurements in a Doubly Spin-Labeled Protein by a Four-Pulse, Double Electron-Electron Resonance Method”, Magn. Reson. Chem., 46, 1096-1101

22. C.D. Rodrigues*, M. Hannus*, M. Prudêncio*, C. Martin, L.A. Gonçalves, S. Portugal, S. Epiphanio, A. Akinc, P. Hadwiger, K. Jahn-Hofmann, I. Röhl, G.J. van Gemert, J.F. Franetich, A.J. Luty, R. Sauerwein, D. Mazier, V. Koteliansky, H.P. Vornlocher, C.J. Echeverri, M.M. Mota (2008) “Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection”, Cell Host & Microbe, 11, 4, 271-282, (* Equally contributing authors)

21. O. Silvie, M.M. Mota, K. Matuschewski,  M. Prudêncio (2008) “Interactions of the malaria parasite and its mammalian host”, Curr. Opin. Microbiol., 11, 352-359 (Review)

20. M. Cunha-Rodrigues§, S. Portugal§, M. Prudêncio, L.A. Gonçalves, C. Casalou, D. Buger, R. Sauerwein, W. Haas, M.M. Mota (2008) “Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy”, PLoS ONE, 3, e2732 (§ Equally contributing authors)

19. M.D. Vlasie, R. Fernández-Busnadiego, M. Prudêncio, M. Ubbink (2008) “Conformation of Pseudoazurin in the 152 kDa Electron Transfer Complex with Nitrite Reductase Determined by Paramagnetic NMR”*; J. Mol. Biol., 375, 1405-1415 (*Issue cover)

18. M. Prudêncio*, C.D. Rodrigues, R. Ataíde, M.M. Mota*(2008), “Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry”, Cell. Microbiol., 10, 218-224 (* Corresponding authors)

17. M. Prudêncio, M.M. Mota (2007), “To migrate or to invade: those are the options”, Cell Host & Microbe, 2, 286-288 (Review)

16. M. D. Vlasie, C. Comuzzi, A. M. C. H. van den Nieuwendijk, M. Prudêncio, M. Overhand, M. Ubbink (2007), “Long-range-distance NMR effects in a protein labeled with a lanthanide–DOTA chelate”, Chem. Eur. J., 13, 1715 – 1723

15. T.E. de Jongh, A.-M. van Roon, M. Prudêncio, M. Ubbink, G.W. Canters (2006), “Click chemistry with an active site variant of azurin”, Eur. J. Inorg. Chem., 3861-3868

14. M. Prudêncio, A. Rodriguez, M.M. Mota (2006), “The silent path to thousands of merozoites: the Plasmodium liver stage”, Nat. Rev. Microbiol., 4, 849-856 (Review)

13. M. Cunha-Rodrigues, M. Prudêncio, M.M. Mota, W. Haas (2006) “Antimalarial drugs – host targets (re)visited”, Biotechnol. J., 1, 321-332 (Review)

12. J.A. Worrall, R.E. Diederix, M. Prudêncio, C.E. Lowe, S. Ciofi-Baffoni, M. Ubbink, G.W. Canters (2005) “The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding”, ChemBioChem, 6, 747-758

11. R.L. Harris, M. Prudêncio, S.S. Hasnain, R.R. Eady and G. Sawers (2005) “Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans”, J. Synchrotron Rad., 12, 13–18

10. M. Prudêncio, M. Ubbink (2004) “Transient Complexes of Redox Proteins: Structural and Dynamic Details from NMR Studies”, J. Mol. Recognit., 17, 524-539 (Review)

9. M. Prudêncio, J. Rohovec, J.A. Peters, E. Tocheva, M.J. Boulanger, M.E.P. Murphy, H.-J. Hupkes, W. Kosters, A. Impagliazzo, M. Ubbink (2004) “A Caged Lanthanide Complex as a Paramagnetic Shift Agent for Protein NMR”, Chem. Eur. J., 10, 3252-3260

8. O. Farver, R.R. Eady, G. Sawers, M. Prudêncio, I. Pecht (2004) “Met144Ala Mutation of the Copper-Containing Nitrite Reductase from Alcaligenes xylosoxidans reverses the Intramolecular Electron Transfer”, FEBS Lett., 561, 173-176

7. M. Prudêncio, G. Sawers, S.A. Fairhurst, F.K. Yousafzai, R.R. Eady (2002) “Alcaligenes xylosoxidans Dissimilatory Nitrite Reductase: Alanine Substitution of the Surface-exposed Histidine 139 Ligand of the Type 1 Copper Center Prevents Electron Transfer to the Catalytic Center”, Biochemistry, 41, 3430-3438

6. M.J. Ellis, M. Prudêncio, F.E. Dodd, R.W. Strange, G. Sawers, R.R. Eady, S.S. Hasnain (2002) “Biochemical and Crystallographic Studies of the Met144Ala, Asp92Asn and His254Phe Mutants of the Nitrite Reductase from Alcaligenes xylosoxidans Provide Insight into the Enzyme Mechanism”, J. Mol. Biol., 316, 51-64

5. M.J. Ellis, F.E. Dodd, R.W. Strange, M. Prudêncio, G. Sawers, R.R. Eady, S.S. Hasnain (2001) “X-ray Structure of a Blue Copper Nitrite Reductase at High pH and in Copper-free Form at 1.9 Angstrom Resolution”, Acta Crystallogr. D, 57, 1110-1118

4. M. Prudêncio, R.R. Eady, G. Sawers (2001) “Catalytic and Spectroscopic Analysis of Blue Copper-containing Nitrite Reductase Mutants Altered in the Environment of the Type 2 Copper Centre: Implications for Substrate Interaction”, Biochem. J., 353, 259-266

3. M. Prudêncio, A.S. Pereira, P. Tavares, S. Besson, I. Cabrito, K. Brown, B. Samyn, B. Devreese, J. Van Beeumen, F. Rusnak, G. Fauque, J. J. G. Moura, M. Tegoni, C. Cambillau and I. Moura (2000) “Purification, Characterization and Preliminary Crystallographic Study of Copper-Containing Nitrous Oxide Reductase from Pseudomonas nautica 617”, Biochemistry, 39, 3899-3907

2. K. Brown, M. Tegoni, M. Prudêncio, A.S. Pereira, S. Besson, J. J. G. Moura, I. Moura and C. Cambillau (2000) “A Novel Type of Catalytic Copper Cluster in Nitrous Oxide Reductase”, Nature Struct. Biol., 7, 191-195

1. M. Prudêncio, R. R. Eady, and G. Sawers (1999) “The Blue Copper-containing Nitrite Reductase from Alcaligenes xylosoxidans: Cloning of the nirA gene and Characterisation of the Recombinant Enzyme”, J. Bact., 181, 2323-2329