Miguel Prudêncio

Researcher. Biological Sciences. Malaria

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Publications

Index

Author databases

Theses

M. Prudêncio (2000) “Molecular Enzymology of the Copper-Containing Enzymes Involved in Denitrification”, PhD Thesis, University of East Anglia

Book Chapters

 L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Ranga-Prasad, J. Meissner, A. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M.P. Rodrigues, M. Mota, V. Sundaramurthy (2021) “Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite’s Liver Stage Development”, In Lange, S. and Ramirez, M.I. (Eds) Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses, Frontiers Media SA, Lausanne. doi: 10.3389/978-2-88966-580-8

A.M. Mendes, A. Scholzen, A.K. Mueller, S.M. Khan, R.W. Sauerwein, M. Prudêncio(2017) “Whole Organism Pre-Erythrocytic Vaccines”, In: Rodriguez, A. and Mota M.M. (Eds) Malaria: immune response to infection and vaccination, Springer International Publishing, Cham, Switzerland

M. Prudêncio, C.D. Rodrigues, M.M. Mota (2006) “The relevance of host genes in Malaria”, In: Parrington,J. and Coward, K. (Eds) Comparative Genomics and Proteomics in the Identification of New Drug Targets, Taylor & Francis, Oxford, UK, SEB Exp. Biol. Ser., 58, 47-91

Opinion Articles and Essays

5. M. Prudêncio (2021) “The role of science during pandemics”, In ‘Highlights 2020, Instituto de Medicina Molecular João Lobo Antunes’, Lisboa, Portugal

4. M.M. Mota, M. Prudêncio (2021) “O tempo em biologia / Time in biology”. In ‘O tempo na ciência e na música / Time in science and music’, Norprint Artes Gráficas, S.A., Santo Tirso, Portugal

3. M.M. Mota, M. Prudêncio (2021) “O tempo em biologia / Time in biology”. In ‘O tempo na ciência e na música / Time in science and music’, Norprint Artes Gráficas, S.A., Santo Tirso, Portugal

2. M. Prudêncio (2020) “In fairness to mosquitoes”, Trends in Parasitology, 36, 876-877

1. M. Prudêncio, J.C. Costa (2020) “Research funding after COVID-19”, Nature Microbiol., 5, 986

Scientific Articles

  1. M. Marinović, H. Rimac, L.P. de Carvalho, C. Rôla, S. Santana, K. Pavić, J. Held, M. Prudêncio, Z. Rajić (2023), “Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines”, Bioorg. Med. Chem., 94, 117468
  1. M.J. Oliveira, S. Caetano, A. Dalot, F. Sabino,  T.R. Calmeiro, E. Fortunato, R. Martins, E. Pereira,  M. Prudêncio, H.J. Byrne, R. Franco,  H. Águas (2023) “A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites” Analyst, 148, 4053
  1. G. da Silva, A.F.S. Luz, D. Duarte, D. Fontinha, V.L.M. Silva, F.A.A. Paz, A.M. Madureira, S. Simões,M. Prudêncio, F. Nogueira, A.M.S. Silva, R. Moreira (2023) “Facile access to structurally diverse antimalarial indoles using a one-pot A3 coupling and domino cyclization approach”, ChemMedChem, 18,  e2023002
  1. S.S. Mendes, M. Sorg, C.M. Luís, D. Fontinha, D. Francisco, D. Moita, C.C. Romão, M.G. Pinho, C. Pimentel,M. Prudêncio, L.M. Saraiva (2023), “Conjugated Carbon Monoxide Releasing Molecules have broad-spectrum antimicrobial activity”, Fut. Med Chem., 15, 12, doi.org/10.4155/fmc-2023-0103
  1. M. Fonte, D. Fontinha, D. Moita, O. Caño-Prades, Y. Avalos-Padilla, X. Fernàndez-Busquets,M. Prudêncio, P. Gomes, C. Teixeira (2023), “New 4-(N-cinnamoylbutyl) aminoacridines as potential multi-stage antiplasmodial leads”, Eur. J. Med. Chem., 258, 115575
  1. K.H. Breiterová, A. Ritomská, D. Fontinha, J. Kroustková, D. Suchánková, A. Hošt’álková, M. Šafratová, E. Kohelová, R. Perinová, R. Vrabec, D. Francisco,M. Prudêncio, Lucie Cahlíková (2023) “Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro”, Pharmaceutics, 15, 1007
  1. J.F. Santos, R. Azevedo,M. Prudêncio, F. Marques, Y. Le Gal, D. Lorcy, C. Fernandes (2023) “Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity”, Pharmaceutics,15, 1030
  1. D. Moita, T.G. Maia, M. Duarte, C.M. Andrade, I.S. Albuquerque, A. Dwivedi, J.C. Silva, L. González-Céron, C.J. Janse, A.M. Mendes,M. Prudêncio (2022) “A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria”, NPJ Vaccines, 7, 163, 1-9
  1. B. Franke-Fayard, C. Marin-Mogollon, F.J.A. Geurten, S. Chevalley-Maurel, J. Ramesar, H. Kroeze, E Baalbergen, E. Wessels, L. Baron, V. Soulard, T. Martinson, M. Aleshnick, A.T.G. Huijs, A.K. Subudhi, Y. Miyazaki, A.S. Othman, S. K. Kolli, O.A.C. Lamers, M. Roques, R.R. Stanway, S.C. Murphy, L. Foquet, D. Moita, A.M. Mendes,M. Prudêncio, K.J. Dechering, V.T. Heussler, A. Pain., B.K. Wilder, M. Roestenberg, C.J. Janse (2022) “Creation and preclinical 1 evaluation of genetically attenuated malaria parasites arresting growth late in the liver”, NPJ Vaccines, 7, 139, 1-17
  1. A.J. Alves, N.G. Alves, I. Bártolo, D. Fontinha, S. Caetano,M. Prudêncio, N.Taveira, T.M. Pinho e Melo (2022) “Unveiling a family of spiro‐beta‐lactams with anti-HIV and anti-plasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates”, Front. Chem., 10, 1017250
  1. H. Nunes-Cabaço, D. Moita,M. Prudêncio(2022) “Five decades of clinical assessment of whole-sporozoite malaria vaccines”, ront. Immunol., 13, 977472
  1. I. Bouzón-Arnáiz; Y. Avalos-Padilla; A. Biosca; O. Caño-Prades; L. Román-Álamo; J. Valle; D. Andreu; D. Moita;M. Prudêncio; E.M. Arce; D. Muñoz-Torrero; X. Fernàndez-Busquets (2022) “The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures”, BMC Biology, 20, 197, 1-27
  1. Y. Le Gal, A. Filatre-Furcate, D. Lorcy, O. Jeannin, T. Roisnel, V. Dorcet, D. Fontinha, D. Francisco, M. Prudêncio, M. Martins, C. Soeiro, S.A. Sousa, J.H. Leitão, T.S. Morais, I. Bártolo, N. Taveira, J.F. Guerreiro, F. Marques (2022) “Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes”,Int. J. Mol. Sci., 23, 7146
  1. C.S. Pereira, H.C. Quadros, S.Y. Aboagye, D. Fontinha, S. D’Alessandro, M.E. Byrne, M. Gendrot, I. Fonta, J. Mosnier, D. Rodrigo, M. Moreira, N. Basilico, D.L. Williams,M. Prudêncio, B. Pradines, M. Navarro (2022) “Hybrid of amodiaquine and primaquine linked by gold(I) is a multistage antimalarial agent by targeting heme detoxification and thiol redox homeostasis”, Pharmaceutics, 14, 1251
  1. A. Khandelwal, F. Arez, P.M. Alves, L. Badolo, C. Brito, C. Fischli, D. Fontinha, C. Oeuvray,M. Prudêncio, M. Rottmann, J. Wilkins, Ö. Yalkinoglu, W.M. Bagchus, T. Spangenberg (2022) “Translation of liver stage activity of M5717, a Plasmodium Elongation Factor 2 inhibitor – from bench to bedside”, Malaria J., 21, 151
  1. H. Nunes-Cabaço, D. Moita, C. Rôla, A.M. Mendes,M. Prudêncio (2022) “Impact of dietary protein restriction on the immunogenicity and efficacy of whole-sporozoite malaria vaccination”, Front. Immunol., 13, 869757
  1. E.A. Lopes, R. Mestre, D. Fontinha,J. Legac, J.V. Pei, M. Sanches-Vaz, M. Mori, A.M. Lehane, P.J. Rosenthal, M. Prudêncio, M.M.M. Santos (2022) “Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity”, Eur. J. Med. Chem, 236, 114324
  1. D. Jublot, P. Cavaillès, S. Kamche, D. Francisco, D. Fontinha,M. Prudêncio, J.-F. Guichou, G. Labesse, D. Sereno, C. Loeuillet (2022)  “A Histone deacetylase (HDAC) inhibitor with pleiotropic in vitro anti-Toxoplasma and Plasmodial activities controls acute and chronic toxoplasma infection in mice”, Int. J. Mol. Sci., 23, 3254
  1. D. Fontinha*, F. Arez*, I.R. Gal, G. Nogueira, D. Moita, T.H.H. Baeurle, C. Brito, T. Spangenberg**, P.M. Alves**,M. Prudêncio** (2022) “Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models”, ACS Inf. Dis., 8, 721-727. *Equally contributing authors; **Corresponding authors.
  1. A.F. Chora, M.M. Mota,M. Prudêncio(2022) “The reciprocal influence of the liver and blood stages of the malaria parasite’s life cycle”, Int. J. Parasitol., 52, 711-715
  1. S. Portugal, A. Rodriguez,M. Prudêncio (2022) “Maria M. Mota: Bringing Plasmodium Liver Infection to the Centre Stage of Malaria Research”, Front. Cell. Infect. Microbiol., 12, 851484
  1. L. Singh, D. Fontinha, D. Francisco,M. Prudêncio, K. Singh (2022) “Synthesis and Antiplasmodial Activity of Regioisomers and Epimers of Second-Generation Dual Acting Ivermectin Hybrids“, Sci. Rep., 12, 564
  1. C. Upadhyay, N. Sharma, S. Kumar, P.P. Sharma, D. Fontinha, B.S. Chhikara, B. Mukherjee, D. Kumar,M. Prudêncio, A.P. Singh, Poonam (2022) “Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum”, New. J. Chem., 46, 250
  1. A.T. Silva, I.S. Oliveira, J. Gomes, L. Aguiar, D. Fontinha, D. Duarte, F. Nogueira,M. Prudêncio, E.F. Marques, C. Teixeira, R. Ferraz, P. Gomes (2021) “Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase blood-stage antimalarial activity of primaquine“, ChemMedChem, e202100650
  1. H.C. Quadros, A. Çapcı, L. Herrmann, S. D’Alessandro, D. Fontinha, R. Azevedo, W. Villarreal, N. Basilico,M. Prudêncio, S.B. Tsogoeva, D.R.M. Moreira (2021) “Studies of Potency and Efficacy of an Optimized Dihydroartemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle”, Pharmaceuticals, 14, 1129
  1. T. Araki*, J. Lin*,M. Prudêncio*, D.A. Cunningham*, T. Annoura* (2021), “Editorial Malaria Targeting Toolkit: Host-Parasite Interactions”Front. Cell. Infect. Microbiol., 11, 795494.  *Corresponding authors 
  1. A. Temporão*, M. Sanches-Vaz*, R. Luís, H. Nunes-Cabaço, T.K. Smith, M. Prudêncio**, L. Figueiredo** (2021) “Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection”, PLoS Negl. Trop. Dis., October 29. * Equally contributing authors; **Corresponding authors. Recommended by Faculty Opinions
  1. M. Marinović, G. Poje, I. Perković, D. Fontinha,M. Prudêncio, J. Held, L.P. Carvalho, T. Tandarić, R. Vianello, Z. Rajić (2021), “Further investigation of harmicines as novel antiplasmodial agents: Synthesis,structure-activity relationship and insight into the mechanism of action”,Eur. J. Med. Chem., 224, 113687
  1. C.S.Pereira, H.C. Quadros, D.R.M. Moreira, W. Castro, Silva R.I.S.D.S., M.B.P. Soares, D. Fontinha, M. Prudêncio, V. Schmitz, H.F. Santos, M. Gendrot, I. Fonta, J. Mosnier, B. Pradines, M.Navarro (2021), “A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent”,ChemMedChem, 16, 662-678
  1. D. Moita, H. Nunes-Cabaço, A.M. Mendes,M. Prudêncio (2021) “A guide to investigating immune responses elicited by whole-sporozoite pre-erythrocytic vaccines against malaria”, FEBS J., doi:10.1111/febs.16016
  1. T.A. Tavella, N.S.M. Silva, N. Spillman, A.C.A.V.K., G.C. Cassiano, A.A. Vasconcelos, A.P. Camargo, D.C.B. Silva, D. Fontinha, L.C.S. Alvarez, L.T. Ferreira, K.C.P. Tomaz, B.J. Neves, L.D. Almeida, D.Y. Bargieri, M.V.G. Lacerda, P.V.L. Cravo, P. Sunnerhagen,M. Prudêncio, C.H. Andrade, S.C.P. Lopes, M.F. Carazzolle, L. Tilley, E. Bilsland, J.C. Borges, F.T.M. Costa (2021) “Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity”ACS Infect. Dis., 7, 759-776
  1. N.G. Alves, I. Bártolo, A.J.S. Alves, D. Fontinha, D. Francisco, S.M.M. Lopes, M.I.L. Soares, C. J.V. Simões,M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2021) “Synthesis and structure-activity relationships of new chiral spiro-b-lactams highly active against HIV-1 and Plasmodium”, Eur. J. Med. Chem., 219, 113439
  1. M. Prudêncio(2021) “Portugal’s prominence in malaria research”, EMBO Reports, e51692
  1. I Bártolo, B.S. Santos, D. Fontinha, M. Machado, D. Francisco, B. Sepodes, J. Rocha, H. Mota-Filipe, R. Pinto, M.E. Figueira, H. Barroso, T. Nascimento, A.P.A. de Matos, A.J.S. Alves, N.G. Alves, C.J.V. Simões,M. Prudêncio, T.M.V.D. Pinho e Melo, N. Taveira (2021) “Spiro-β-lactam BSS-730A displays potent activity against HIV and Plasmodium”,ACS Infectious Diseases, 7, 2, 421-434
  1. M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M.J. Araújo, X. Fernàndez-Busquets,M. Prudêncio, P. Gomes, C. Teixeira (2021) “4,9-diaminoacridines and 4-aminoacridines as antiplasmodial hits”.ChemMedChem, 16, 799-792
  1. Y. Miyazaki, C.Y. Marin, T. Imai, A.M. Mendes, R. vd Laak, A. Sturm, F.J. Geurten, S. Miyazaki, S.C. Chevalley-Maurel, J. Ramesar, S.K. Kolli, J. Kroeze, R. van Schuijlenburg, A.M. Salman, B.K. Wilder, A. Reyes-Sandoval, K. Dechering, M. Prudêncio, C.J. Janse, S.M. Khan, B. Franke-Fayard (2020) “Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing P. vivax circumsporozoite protein for malaria vaccine development”, Frontiers in Cellular and Infection Microbiology, 10, 591046
  1. P. Meireles, D. Brás, D. Fontinha, A.F. Chora, K. Serre, A.M. Mendes*, M. Prudêncio* (2020) “Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation”, iScience, 23, 101781(*Corresponding authors). Recommended by Faculty Opinions
  1. M. Marinović, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L. Pessanha de Carvalho, T. Tandarić, R. Vianello, B. Zorc, Z. Rajić (2020) “Novel Harmicines with Improved Potency against Plasmodium”, Molecules, 25, 4376
  1. M. Prudêncio(2020) “In fairness to mosquitoes”, Trends in Parasitology, 36, 876-877
  1. S.A. Milheiro, J. Gonçalves, R.M.R.M. Lopes, M. Madureira, L. Lobo, A. Lopes, F. Nogueira, D. Fontinha, M. Prudêncio, M.F.M. Piedade, S.N. Pinto, P.R. Florindo, R. Moreira (2020) “Half- sandwich cyclopentadienylruthenium(II) complexes: a new antimalarial chemotype”, Inorganic Chemistry, 59, 12722-12732
  1. D. Fontinha, I. Moules, M. Prudêncio(2020) “Repurposing drugs to fight hepatic malaria parasites”, Molecules, 25, 3409
  1. M. Prudêncio, J.C. Costa (2020) “Research funding after COVID-19”, Nature Microbiol., 5, 986
  1. D. Fontinha, S.A. Sousa, T.S. Morais, M. Prudêncio, J.H. Leitão, Y.L. Gal, D. Lorcy, R.A.L. Silva, M.F.G. Velho, D. Belo, M. Almeida, J.F. Guerreiro, T. Pinheiro, F. Marques (2020) “Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents”, Metallomics, 12, 974-987
  1. I.J. Reuling *, A.M. Mendes*, G.M. de Jong GM*, A. Fabra-García*, H. Nunes-Cabaço*, G.J. van Gemert, W. Graumans, L.E. Coffeng, S.J. de Vlas, A.S.P. Yang, C.K. Lee, Y. Wu, A.J. Birkett, C.F. Ockenhouse, R. Koelewijn, J.J. van Hellemond, P.J.J. van Genderen**, R.W. Sauerwein**, M. Prudêncio** (2020) “Safety and efficacy of a genetically modified rodent malaria parasite against Plasmodium falciparum malaria: an open-label randomized phase 1/2a trial”, Science Transl. Med.,12, eaay2578. *Equally contributing authors; **Corresponding authors. Issue cover.
  1. L. Singh, D. Fontinha, D. Francisco, A.M. Mendes, M. Prudêncio, K. Singh (2020) “Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites”, J. Med. Chem., 63, 1750-1762
  1. R. Azevedo, A.M. Mendes, M. Prudêncio(2020) “The impact of antiretroviral therapy on malaria parasite transmission”, Frontiers in Microbiology, 10, 3048
  1. L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Prasad, J. Meissner, A.S. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M. Rodrigues, M.M. Mota, V. Sundaramurthy (2020) “Association of Plasmodium berghei with the apical domain of hepatocytes is necessary for the parasite’s liver stage development”, Frontiers in Cellular Infection Microbiology,9, 451
  1. I. Perković, S. Raić-Malić, D. Fontinha, M. Prudêncio, L.P. Carvalho, J. Held, T. Tandarić, R. Vianello, B. Zorc, Zrinka Rajić (2020) “Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits”, European Journal of Medicinal Chemistry, 187, 11927
  1. S.A. Sousa, J.H. Leitão, R.A.L. Silva, D. Belo, I.C. Santos, J.F. Guerreiro, M. Martins, D. Fontinha, M. Prudêncio, M. Almeida, D. Lorcy, F. Marques (2020) “On the Path to Gold: Monoanionic Au Bisdithiolate Complexes with 1 Antimicrobial and Antitumor Activities”, Journal of Inorganic Biochemistry, 202, 110904
  1. A.J.S. Alves, N.G. Alves, C.C. Caratão, Esteves M., D. Fontinha, I. Bártolo, M.I.L. Soares, S.M.M. Lopes, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2020) “Spiro-Lactams as Novel Antimicrobial Agents”, Curr. Top. Med. Chem., 20, 140-152
  1. M. Sanches-Vaz, A. Temporão, R. Luis, H. Nunes-Cabaço, A.M. Mendes, S. Goellner, T. Carvalho, L.M. Figueiredo*, M. Prudêncio* (2019) “Trypanosoma brucei infection protects mice against malaria”, PLoS Pathogens, 15, e1008145(* Corresponding authors)
  1. R. Azevedo, A.M. Mendes,M.Prudêncio(2019) “Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins”, Parasites & Vectors, 12, 594
  1. F. Arez, S. Rebelo, D. Fontinha, D. Simão, T.R. Martins, M. Machado, C. Fischli, C. Oeuvray, L. Badolo, M. J. T. Carrondo, M. Rottmann, T. Spangenberg, C. Brito, B. Greco*,M. Prudêncio*, P.M. Alves* (2019) “Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection”, ACS Infect. Dis., 5, 1831-1842 (* Corresponding authors)
  1. K. Pavić, B. Rubinić, Z. Rajić, D. Fontinha, M. Prudêncio, L. Uzelac, M. Kralj, J. Held, B. Zorc (2019) “Primaquine homodimers as potential antiplasmodial and anticancer agents”, Bioorganic & Medicinal Chemistry Letters,29, 126614
  1. K. Wolanin, D. Fontinha, M. Sanches‐Vaz, B. Nyboer, Kirsten Heiss, A.-K. Mueller, M. Prudêncio(2019) “A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle”, Cell. Microbiol., e13088
  1. M. Beus, D. Fontinha, J. Held, Z. Rajić, L. Uzelac, M. Kralj, M. Prudêncio, B. Zorc (2019) “Primaquine and chloroquine fumardiamides as promising antiplasmodial agents”, Molecules, 24, 2812
  1. M. Beus, D. Fontinha, J. Held, Z. Rajić, M. Prudêncio, B. Zorc (2019) “Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides”, Acta Pharmaceutica, 69, 233-248
  1. L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, Paula Gomes (2019) “Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites”, MedChemComm, 10, 221-226
  1. G. Mayoka, M. Njoroge, J. Okombo, L. Gibhard, M. Sanches-Vaz, D. Fontinha, L.M. Birkholtz, J. Reader, M. van der Watt, T.L. Coetzer, S. Lauterbach, A. Churchyard, B. Bezuidenhout, T.J. Egan, C.L. Yeates, S. Wittlin, M. Prudêncio, K. Chibale (2019) “Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria”, J. Med. Chem., 62, 1022-1035
  1. M. Kumar, J. Okombo, D. Mambwe, D. Taylor, N. Lawrence, J. Reader, M.V. Watt, D. Fontinha, M. Sanches-Vaz, B. Bezuidenhout, S. Lauterbach, D. Liebenberg, L.M. Birkholtz, T.L. Coetzer, M. Prudêncio, T.J. Egan, S. Wittlin, K. Chibale (2019) “Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action”, ACS Infect. Dis., 5, 303-315
  1. A.M. Mendes, I.J. Reuling, C.M. Andrade, T.D. Otto, M. Machado, F. Teixeira, J. Pissarra, N. Gonçalves-Rosa, D. Bonaparte, J. Sinfrónio, M. Sanders, C.J. Janse, S.M. Khan, C.I. Newbold, M. Berriman, C. Lee, Y. Wu, C.F. Ockenhouse, R.W. Sauerwein, M. Prudêncio(2018) “Pre-Clinical Evaluation of a P. berghei-Based Whole-Sporozoite Malaria Vaccine Candidate”, NPJ Vaccines, 3, 54
  1. M. Beus, Z.R. Džolić, D. Maysinger, Z. Mlinarić, M. Antunović, I. Marijanović, D. Fontinha, M. Prudêncio, J. Held, S. Olgen, B. Zorc (2018) “SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents”, ChemistryOpen,7, 624-638
  1. A.M. Mendes, M. Machado, N. Gonçalves-Rosa, I.J. Reuling, L. Foquet, C. Marques, A.M. Salman, A.S.P. Yang, K.A. Moser, A. Dwivedi, C.C. Hermsen, B. Jiménez-Díaz, S. Viera, J.M. Santos, I. Albuquerque, S.N. Bhatia, J. Bial, I. Angulo-Barturen, J.C. Silva, G. Leroux-Roels, C.J. Janse, S.M. Khan, M.M. Mota, R.W. Sauerwein, M. Prudêncio(2018) “A Plasmodium berghei Sporozoite-Based Vaccination Platform Against Human Malaria”, NPJ Vaccines, 3, 33
  1. R. Capela, J. Magalhães, D. Miranda, M. Machado, M. Sanches-Vaz, I.S. Albuquerque, M. Sharma, J. Gut, P.J. Rosenthal, R. Frade, M.J. Perry, R. Moreira, M. Prudêncio*, F. Lopes* (2018) “Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability”, Eur. J. Med. Chem., 149, 69-78. *- Corresponding authors
  1. M. Šafratová, A. Hošťálková, D. Hulcová, K. Breiterová, V. Hrabcová, M. Machado, D. Fontinha, M. Prudêncio, J. Kuneš, J. Chlebek, D. Jun, M. Hrabinová, L. Nováková, R. Havelek, M. Seifrtová, L. Opletal, L. Cahlíková (2018) “Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity”, Arch. Pharm. Res., 41, 208-218
  1. K. Pavic, I. Perkovic, S. Popisilova, M. Machado, D. Fontinha, M. Prudêncio, J. Jampilek, A. Coffey, L. Endersen, H. Rimac, B. Zorc (2018) “Primaquine hybrids as promising antimycobacterial and antimalarial agents”, Eur. J. Med. Chem., 143, 769-779
  1. T.S. Macedo, W. Villarreal, C.C. Couto, D.R.M. Moreira, M. Navarro, M. Machado, M. Prudêncio, A.A. Batista, M.B.P. Soares (2017) “Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function”, Metallomics, 9, 1548-1561
  1. M. Machado, M. Sanches-Vaz, J.P. Cruz, A.M. Mendes, M. Prudêncio (2017) “Inhibition of Plasmodium hepatic infection by antiretroviral compounds”, Front. Cell. Infect. Microbiol., 7, DOI: 10.3389/fcimb.2017.00329
  1. P. Meireles, A.M. Mendes, R.I. Aroeira, B.C. Mounce, M. Vignuzzi, H.M. Staines, M. Prudêncio(2017) “Uptake and metabolism of arginine impact Plasmodium development in the liver”,Sci. Rep., 7, 4072
  1. R. Azevedo, M. Markovic, M. Machado, B. Franke-Fayard, A.M. Mendes, M. Prudêncio(2017) “A bioluminescence method for in vitro screening of Plasmodium transmission-blocking compounds”, Antimicrob. Agents Chemother., 61, 202699-16
  1. K. Singh, J. Okombo, C. Brunschwig, F. Ndubi, L. Barnard, C. Wilkinson, P.M. Njogu, M. Njoroge, L. Laing, M. Machado, M. Prudêncio, J. Reader, M. Botha, S. Nondaba, L.M. Birkholtz, S. Lauterbach, A. Churchyard, T.L. Coetzer, J.N. Burrows, C. Yeates, P. Denti, L. Wiesner, T.J. Egan, S. Wittlin, K. Chibale (2017) “Antimalarial pyrido[1,2-a]benzimidazoles: Lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics and in vivo oral efficacy in a mouse model”, J. Med. Chem., 60, 1432-1448
  1. C.S. Cunha§, B. Nyboer§, K. Heiss, M. Sanches-Vaz, D. Fontinha, E. Wiedtke, D. Grimm, J.M. Przyborski, M.M. Mota, M. Prudêncio*, A.K. Mueller* (2017) “P. berghei EXP-1 Interacts with Host Apolipoprotein H during Plasmodium Liver Stage Development”, Proc. Natl. Acad. Sci. USA, 114, E1138-E1147. §- Equally contributing authors; *- Corresponding authors
  1. A.M. Mendes, I.S. Albuquerque, M. Machado, J. Pissarra, P. Meireles, M. Prudêncio(2017) “Inhibition of Plasmodium liver infection by ivermectin”, Antimicrob. Agents Chemother., 61, e02005-16
  1. M.A.S. Cavadas, M.P. Monopoli, C.S. Cunha, M. Prudêncio, E. Pereira, I. Lynch, K.A. Dawson, R. Franco (2016) “Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates”, Particle & Particle Systems Characterization, 33, 906-915
  1. Carrasco M.P.*, Machado M., Gonçalves L., Sharma M., Gut J., Lukens A.K., Wirth D.F., André V., Duarte M.T., Guedes R.C., Dos Santos D., Rosenthal P.J., Mazitschek R., Prudêncio M.*, Moreira R. (2016) “Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites”, ChemMedChem, 11, 2194-2204 (* Corresponding authors)
  1. P. Meireles, J. Sales-Dias, C.M. Andrade, J. Mello-Vieira, L. Mancio-Silva, J.P. Simas, H.M. Staines, M. Prudêncio (2016) “GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection”, Cell. Microbiol., doi:10.1111/cmi.12646
  1. R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado,M. Prudêncio, S. Parapini, S. D’Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes (2016) “Primaquine-based ionic liquids as a novel class of antimalarial hits”, RSC Advances, 6, 56134-56138
  1. T.S. Macedo, L.C. Vegas, M. Paixão, M. Navarro, B.C. Barreto, P.C.M..Oliveira, S.G. Macambira, M. Machado, M. Prudêncio, S. D’Alessandro, N. Basilico, D.R.M. Moreira, A.A. Batista, M.B.P. Soares (2016) “Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents”, Parasitology, 143, 1543-1556
  1. C.J.A. Ribeiro, M. Espadinha, M. Machado, J. Gut, L.M. Gonçalves, P.J. Rosenthal, M. Prudêncio, R. Moreira, M.M.M. Santos (2016) “Novel squaramides with in vitro liver stage antiplasmodial activity”, Bioorg. Med. Chem., 24, 1786-1792
  1. N. Terzić, J. Konstantinović, M. Tot, J. Burojević, O. Djurković-Djaković, J. Srbljanović, T. Štajner, T. Verbić, M. Zlatović, M. Machado, I.S. Albuquerque, M. Prudêncio*, R.J. Sciotti, S. Pecic, S. D’Alessandro, D. Taramelli, B.A. Šolaja* (2016) “Re-investigating old pharmacophores: Are 4-aminoquinolines and tetraoxanes potential two-stage antimalarials?”,J. Med. Chem., 59, 264-281(* Corresponding authors)
  1. I. Gomes, A. Reis, E. Pereira, E. Fortunato, M. Prudêncio, R. Franco (2015) “Nanoimunoensaios para diagnóstico de malária”,An. Inst. Hig. Med. Trop., 14, 21-30
  1. N.A.L. Pereira, Â. Monteiro, M. Machado, J. Gut, E. Molins, M.J. Perry, J. Dourado, R. Moreira, P.J. Rosenthal,M. Prudêncio,* and M.M.M. Santos* (2015), “Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites”.ChemMedChem, 10, 2080-2089 (* Corresponding authors)
  1. A. Gomes, M. Machado, L. Lobo, F. Nogueira,M. Prudêncio, C. Teixeira, P. Gomes (2015) “N-cinnamoylation of antimalarial classics: Effects of using acyl groups other than cinnamoyl toward dual-stage antimalarials”,ChemMedChem, 10, 1344-1349
  1. H. Kaur, M. Machado, C. de Kock, P. Smith, K Chibale,M Prudêncio, K. Singh (2015) “Primaquineepyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity”,European Journal of Medicinal Chemistry, 101, 266-273
  1. M.D. Lewis, J. Behrends, C.S. Cunha, A.M. Mendes, F. Lasitschka, K. Heiss, T.W.A. Kooij,M.Prudêncio, F.Frischknecht and A.-K. Mueller (2015), “Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression”,Journal of Immunology, 194, 4860-4870
  1. C.A.B. Rodrigues, R.F.M. Frade, I.S. Albuquerque, M.J. Perry, J. Gut, M. Machado, P.J. Rosenthal,M. Prudêncio, C.A.M. Afonso, R. Moreira (2015), “Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids”,ChemMedChem, 10, 883-890
  1. P. Liehl, P. Meireles, I.S. Albuquerque, M. Pinkevych, F. Baptista, M.M. Mota, M.P. Davenport, M. Prudêncio (2015), “Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections”,Infection and Immunity, 83, 1172-1180
  1. C. Ramalhete, F.P. da Cruz, I.J. Sousa, S. Mulhovo, M.X. Fernandes,M. Prudêncio, M.-J.U. Ferreira (2014), “Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite”,Bioorganic & Medicinal Chemistry, 22, 3887-3890
  1. R. Oliveira, R.C. Guedes, P. Meireles, I.S. Albuquerque, L.M. Gonçalves, E. Pires, M.R. Bronze, J. Gut, P.J. Rosenthal,M. Prudêncio, R. Moreira, P.M. O’Neill, F. Lopes (2014), “Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials”,J. Med. Chem., 57, 4916-4923
  1. D. Miranda, R. Capela, I.S. Albuquerque, P. Meireles, I. Paiva, F. Nogueira, R. Amewu, J. Gut, P.J. Rosenthal, R. Oliveira, M.M. Mota, R. Moreira, F. Marti,M. Prudêncio, P.M. O’Neill, F. Lopes (2014) “Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities”,ACS Med. Chem. Lett., 5, 108-112
  1. A. Gomes, B. Pérez, I. Albuquerque, M. Machado, M. Prudêncio, F. Nogueira, C. Teixeira, P. Gomes (2014) “N-cinnamoylation of antimalarial classics: new quinacrine analogues with reduced toxicity and dual-stage activity”, ChemMedChem,9, 305-310
  1. P. Liehl, V. Zuzarte-Luís, J. Chan, T. Zillinger, F. Baptista, D.l Carapau, M. Konert, K. Hanson, C. Carret, C. Lassnig, M. Müller, U. Kalinke, M. Saeed, A.F. Chora, D.T. Golenbock, B. Strobl, M. Prudêncio, L.P. Coelho, S.H. Kappe, G. Superti-Furga, A. Pichlmair, A.M. Vigário, C.M. Rice, K.A. Fitzgerald, W. Barchet, M.M. Mota (2014) “Host cell sensors for Plasmodium activate innate immunity against liver stage infection”, Nature Medicine, 20, 47-53
  1. A.S. Ressurreição, D. Gonçalves, A.R. Sitoe, I.S. Albuquerque, J. Gut, A. Góis, L.M. Gonçalves, M.R. Bronze, T. Hanscheid, G.A. Biagini, P.J. Rosenthal, M. Prudêncio, P. O’Neill, M.M. Mota, F. Lopes, R. Moreira (2013) “Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability”, J. Med. Chem., 56, 7679-7690
  1. T. Rodrigues, A.S. Ressurreição, F.P. da Cruz, I.S. Albuquerque, J. Gut, M. Carrasco, D. Gonçalves, M.M. Mota, P.J. Rosenthal, R. Moreira, M. Prudêncio, F. Lopes (2013) “Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds”, Eur. J. Med. Chem., 69, 872-880
  1. K. Hanson, A.S. Ressurreição, K. Buchholz, M. Prudêncio, J. Herman, M. Rebelo, W. Beatty, D. Wyrth, T. Hanscheid, R. Moreira, M. Marti, M.M. Mota (2013) “Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins”, Proc. Natl. Acad. Sci. USA, 110, E2838-E2847 
  1. T. Rodrigues, F.P. da Cruz, M. Lafuente-Monasterio, D. Gonçalves, A. Ressurreição, A.R. Sitoe, M.R. Bronze, J.Gut, G. Schneider, M.M. Mota, P.J. Rosenthal, M. Prudêncio, F.-J. Gamo, F. Lopes, R. Moreira (2013) “Quinolon-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria”, J. Med. Chem., 56, 4811-4815
  1. E. Dempsey, M. Prudêncio, B.J. Fennell, C.S. Gomes-Santos, J.W. Barlow, A. Bell (2013) “Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites”,Mol. Biochem. Parasitol., 188, 116-127. Highlighted as Feature Article on Malaria Nexus
  1. J. Lin, P. Meireles, M. Prudêncio, S. Engelmann, T. Annoura, M. Sajid, S. Chevalley‐Maurel, J. Ramesar, C. Nahar, C.M.C. Avramut, A.J. Koster, K. Matuschewski, A.P. Waters, C.J. Janse, G.R. Mair, S.M. Khan (2013) “Loss‐of‐Function Analyses Defines Vital and Redundant Functions of the Plasmodium Rhomboid Protease Family”,Mol. Microbiol., 88, 318-338