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European Commission – Horizon Europe 2024-2028
“OptiViVax – Optimising a high efficacy Plasmodium vivax malaria vaccine”
Role: PI
“la Caixa” Foundation 2021-2025
“Whole-organism vaccines against P. falciparum and P. vivax malaria with enhanced efficacy and scope”
Role: PI
Fundação para a Ciência e Tecnologia 2023-2025
“Ivermectin hybrids – potential insecticidal and multistage antiplasmodial drugs for malaria control”
Role: Participant (PI: Diana Fontinha)
GSK Tres Cantos Open Lab Foundation 2021-2022
Prudêncio (PI)
“Generation, characterization and in vivo evaluation of a novel live malaria vaccine”
Role: PI
FCT 2018-2022
Moreira (PI)
“A multitarget strategy to hit all stages of the Plasmodium life-cycle”
Role: Participant
Instituto de Biologia Experimental e Tecnológica (iBET) / Merck
Prudêncio (PI) 2016-2022
“3D hepatic cell models of Plasmodium infection”
Role: PI
Prudêncio (PI)
“Enabling strategies for enhanced whole-sporozoite malaria vaccines”
The goal of this project is to develop methodoloies that will enable the development and deployment of effective whole-sporozoite malaria vaccines”
Role: PI
Merck 2017-2019
Prudêncio (PI)
“Production and maintenance of Plasmodium-infected mosquitoes”
The goal of this project is to enable to production of P. falciparum-infected mosquitoes at iMM Lisboa
Role: PI
PATH Malaria Vaccine Initiative
Prudêncio (PI) 2017-2018
A P. berghei-based vaccine against Malaria
The goal of this project is to pursue the clinical evaluation the PbVac malaria vaccine candidate
Role: PI Presse release here
Mendes (PI) 2016-2019
Improving whole organism vaccines against malaria by genetic modification
The goal of this project if to develop strategies to express multi-stage antigens on Plasmodium sporozoites for vaccination against malaria
Role: Co-Investigator
TwinnToInfect (European Commission, H2020 Twinning, EU)
Mota (Coordinator)
Science- and innovation-driven clustering of Instituto de Medicina Molecular (iMM Lisboa), the Institut Pasteur and the Francis Crick Institute
Role: Participant
PATH Malaria Vaccine Initiative
Prudêncio (PI) 2015-2017
A P. berghei-based vaccine against Malaria
The goal of this project is to pursue the development of a P. berghei-based strategy for vaccination against malaria
Role: PI
OPP1025364 (Bill and Melinda Gates Foundation, Grand Challenges Explorations-Phase II)
Prudêncio (PI) 2013-2017
A New Whole-Organism Vaccine Against Malaria
The goal of this project is to pursue the development of a novel strategy for vaccination against malaria
Role: PI Press release here
PTDC/BIA-BCM/71920/2006 (Foundation for Science and Technology, Portugal)
Prudêncio (PI) 2006-2010
The role of SR-BI in malaria infection
The goal of this study was to investigate the role of the scavenger receptor B-I on invasion and development of liver-stage Plasmodium parasites
Role: PI Final evaluation report here
PTDC/SAU-MII/099118/2008 (Foundation for Science and Technology, Portugal)
Prudêncio (PI) 2008-2012
The influence of bile acids on malaria liver infection
The goal of this project was to investigate the modulation of Plasmodium liver infection by bile acids and nuclear-receptor signaling processes
Role: PI Final evaluation report here.
HMS-PT (Harvard Medical School-Portugal Research Programme)
Mota (PI) 2009-2012
New drugs for treating and eradicating malaria
The goal of this project was develop new anti-malarial compounds based on novel molecular scaffolds identified in various drug screens against Plasmodium liver stages
Role: Co-Investigator
OPP1025364 (Bill and Melinda Gates Foundation, Grand Challenges Explorations – Phase I)
Prudêncio (PI)
A New Whole-Organism Vaccine Against Malaria
The goal of this project was to establish the proof-of-concept of a new vaccination strategy against malaria
Role: PI Press release here.
PTDC-SAU-MIC-117060-2010 (Foundation for Science and Technology, Portugal)
Prudêncio (PI) 2012-2015
Utilization of host cell resources by the malaria parasite in the liver
The goal of this project is to elucidate novel mechanisms of nutrient acquisition by Plasmodium liver stages and identify novel anti-malarial targets
Role: PI Final evaluation report here.
PTDC/SAU-FAR/118459/2010 (Foundation for Science and Technology, Portugal)
Lopes (PI) 2012-2015
Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
The goal of this study is to develop new hybrid molecules with dual-stage activity against Plasmodium parasites
Role: Co-Investigator
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